hello .
In this lesson, we will look at NMN and whether it is effective for sleep .

• NMN

NMN (Nicotinamide mononucleotide) is a substance that increases the concentration of NAD+, which decreases with age , and is a representative substance that is converted to NAD+ in the body . The main functions of NMN are cellular energy activation , DNA repair , and immunity improvement, and it works throughout our body . It has been greatly spotlighted in Korea through a book by Dr. Sinclair, a Harvard doctor of aging , and is currently receiving attention as a representative anti-aging ingredient with various clinical trials being conducted in the United States and Japan .

 

• NMN and sleep

Based on a paper published in February 2022 , we'll tell you whether NMN can help you sleep .

The study described in the paper was conducted to investigate the effects of NMN intake over time on sleep quality , fatigue , and physical ability in the elderly . To this end, 108 participants were divided into four groups . The NMN intake group (n=54 ) was divided into morning (n=27) and afternoon (n=27) groups , and the placebo group (n=54) was divided into morning (n=27) and afternoon (n=27) groups . 108 Japanese volunteers with an average age of 73 years participated in the study, taking NMN (250 mg) or a placebo once a day according to each group for 12 weeks .

To determine whether NMN supplementation improved sleep-related indicators, researchers used a sleep quality assessment tool called the Pittsburgh Sleep Quality Index (PSQI) . This sleep quality assessment tool measures an individual's subjective sleep quality by examining sleep duration , sleep latency , sleep disturbances , and sleep efficiency .

Before analyzing the table, please note that 'd= effectiveness ' . Additionally, this table has been translated into Korean to aid understanding.

Copyright © 2022 Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T.

According to the table above , we can see that the NMN_PM ( NMN afternoon intake group) had significantly longer sleep time than the other groups .

Copyright © 2022 Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T.

According to the table above , we can see that the NMN_PM (NMN afternoon intake group) had a higher sleep quality score than the other groups .


We can conclude that taking 250 mg of NMN per day improves sleep duration and quality, thereby reducing fatigue .

Copyright © 2022 Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T.

Additionally , in addition to measuring the sleep of the subjects above, physical function was also measured, which had a positive effect . As an index for measuring physical function, ' sit-and-stand five times consecutively ' was performed . In the case of the group that took NMN in the afternoon , it showed a significant result, about 1 second faster, unlike the other groups.

Based on this paper, the study's researchers reported in the journal Nutrients that taking 250 mg of NMN in the afternoon for 12 weeks helped improve physical function in older adults by helping them sleep better.

Sleep is a crucial element in replenishing the body's daily energy reserves . As we age, sleep duration and quality decline , leading to insufficient physical and mental fatigue, which can lead to a decline in the quality of daily life .

Therefore, after taking 250 mg of NMN , the significant increase in sleep time , sleep quality , and improvement in motor function can be an alternative for those who feel inconvenienced in their daily lives due to shallow sleep as they age .

NMN suggests that taking it in the afternoon may help with sleep .
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[ Reference material ]

[1] nmn.com

[2] Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022 Feb 11;14(4):755. doi: 10.3390/nu14040755. PMID: 35215405; PMCID: PMC8877443.