Is NMN effective for osteoporosis?
hello .
In this session, we will look at NMN and whether it is effective for osteoporosis .
Prior to this, the cells that make up the bones in our body are called ' bone marrow stem cells ' . As bone marrow stem cells age, cell mutations occur, which reduces the regeneration of stem cells , and as a result, osteoporosis, a representative disease that causes holes in the bones, is induced .
Comparing the two age groups , the study demonstrated that the regenerative capacity of bone stem cells decreases with age , and that blocking the activation of the NAP1L2 protein is necessary to prevent this .
What is noteworthy here is that NMN prevents mutations in cells by blocking NAP1L2 protein activation .
Figure S8 NMN rescues the osteogenic capability of C3H10T1/2 cells overexpressing NAP1L2.
Copyright © 2022 Hu M, Xing L, Zhang L, Liu F, Wang S, Xie Y, Wang J, Jiang H, Guo J, Li X, Wang J, Sui L, Li C, Liu D, Liu Z.
(c) According to the Alizarin Red Staining Test, the redder the color, the more active the bone differentiation progresses , so it can be visually confirmed that the bone differentiation progress is reduced when NMN is added .
You can find it by clicking on the picture below .
In this session, we will look at NMN and whether it is effective for osteoporosis .
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NMN
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NMN and osteoporosis
Prior to this, the cells that make up the bones in our body are called ' bone marrow stem cells ' . As bone marrow stem cells age, cell mutations occur, which reduces the regeneration of stem cells , and as a result, osteoporosis, a representative disease that causes holes in the bones, is induced .
Comparing the two age groups , the study demonstrated that the regenerative capacity of bone stem cells decreases with age , and that blocking the activation of the NAP1L2 protein is necessary to prevent this .
What is noteworthy here is that NMN prevents mutations in cells by blocking NAP1L2 protein activation .
Figure S8 NMN rescues the osteogenic capability of C3H10T1/2 cells overexpressing NAP1L2.
Copyright © 2022 Hu M, Xing L, Zhang L, Liu F, Wang S, Xie Y, Wang J, Jiang H, Guo J, Li X, Wang J, Sui L, Li C, Liu D, Liu Z.
(c) According to the Alizarin Red Staining Test, the redder the color, the more active the bone differentiation progresses , so it can be visually confirmed that the bone differentiation progress is reduced when NMN is added .
NMN offers new therapeutic potential for bone-related diseases.
For additional information about Rokit America NMN, please visit
You can find it by clicking on the picture below .
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[References]
[1] nmn.com
[2] Hu M, Xing L, Zhang L, Liu F, Wang S, Xie Y, Wang J, Jiang H, Guo J, Li Aging Cell. 2022 Feb;21(2):e13551. doi: 10.1111/acel.13551. Epub 2022 Jan 15. PMID: 35032339; PMCID: PMC8844120