NR Glutathione

Nicotinamide Riboside (NR) is a precursor of Vitamin B3 and a unique nutrient that is converted into NAD+ within the body. NAD+ is essential for cellular energy production and maintaining cellular function, but its levels tend to decline with age. As an effective precursor to NAD+, NR has garnered significant attention in the fields of health and anti-aging.

Benefits of Nicotinamide Riboside (NR)

① NR boosts NAD+ levels, activating cellular energy metabolism. This improves mitochondrial function, leading to increased overall energy levels. Studies indicate that NR supplementation can elevate NAD+ levels, reduce fatigue, and help enhance physical endurance.

② By promoting energy production and cellular repair, NR contributes to anti-aging effects for the skin. Research suggests that NR enhances skin resilience and helps protect against UV damage, supporting healthier, more youthful skin.

The figure demonstrates that NR significantly inhibits intracellular melanin production at all tested doses. This suggests that NR not only inhibits melanin secretion but also suppresses the progression of melanin production.

Reference: Yeon Jae Lee, Seul Gi Jang, Min Jeong Ryu, Seung Hee Choi, Nicotinamide Riboside Ameliorates Hyperpigmentation on Photo-Irradiated Skin https://www.mdpi.com/2079-9284/11/3/73

③ Neuroprotection and Cognitive Function Improvement: NR increases NAD+ levels in the brain, supporting the health of neuronal cells. This may help prevent and slow the progression of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

Research findings suggest that NR supplementation can reduce neuroinflammation and improve memory. Notably: In the hippocampus, the brain's memory center, NR is believed to either repair damaged DNA in neurons or prevent further DNA damage. Mice supplemented with NR showed enhanced memory in maze navigation and object recognition tests. Additionally, compared to the control group, NR-treated mice exhibited improved muscle strength, grip, endurance, and gait. These results highlight NR's potential for promoting brain health and physical performance.

Reference: Nicotinamide Riboside Improves Dementia https://www.medicopharma.co.kr/news/articleView.html?idxno=43858

④ Cardiovascular Health Enhancement: NAD+ plays a vital role in maintaining the function of heart and vascular cells. Supplementing NAD+ through NR can lower blood pressure, support vascular health, and reduce the risk of cardiovascular diseases.

In a clinical study where participants consumed 1000 mg of NR daily: NAD+ levels increased by approximately 60%. Notably, among 13 participants with elevated blood pressure or stage 1 hypertension, systolic blood pressure decreased in 11 individuals. These findings suggest that NR supplementation can have a positive effect on blood pressure regulation and overall cardiovascular health.

The Effects of NR on Cardiovascular Health Indicators.

Reference: Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, Chonchol M, Seals DR. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018 Mar 29;9(1):1286. DOI: 10.1038/s41467-018-03421-7. PMID: 29599478; PMCID: PMC5876407.

⑤ Prevention of Diabetes Complications: NR may be effective in preventing diabetes-related complications, particularly peripheral neuropathy. In animal studies: Pre-diabetic and diabetic mice treated with NR did not develop fatty liver (hepatic steatosis). They showed less liver damage and improved blood glucose levels. These findings suggest that NR supplementation can help mitigate complications associated with diabetes.

Reference: Nicotinamide Riboside Prevents Diabetes Complications., https://www.whosaeng.com/101807

⑥ Anti-Aging and Longevity Promotion: NAD+ plays a key role in repairing DNA damage and slowing the cellular aging process. By increasing NAD+ levels, NR helps alleviate the primary causes of cellular aging, promoting healthier and longer cellular function. This makes NR a promising compound for anti-aging and longevity support.

Why is NR Special?

NR stands out because it converts into NAD+ more efficiently compared to other forms of Vitamin B3, with higher bioavailability. It is also gentler on the stomach and has a high safety profile, making it suitable for long-term consumption. Due to these characteristics, NR has gained attention in the health supplement and anti-aging research fields, offering a wide range of health benefits.

S-Acetyl Glutathione is a stabilized form of the antioxidant glutathione, created by attaching an acetyl group to the glutathione molecule to enhance its stability. While regular glutathione may be broken down during digestion and exhibit low absorption rates, S-Acetyl Glutathione is easily absorbed and converted into its active form within the body, demonstrating high bioavailability. Thanks to these properties, S-Acetyl Glutathione is recognized as a more effective ingredient for antioxidant and detoxification functions.

Benefits of S-Acetyl Glutathione:

① Powerful Antioxidant Action: S-Acetyl Glutathione removes reactive oxygen species and free radicals, protecting cells from damage. This can help prevent chronic diseases such as cancer, cardiovascular disease, and diabetes. Notably, acetylated glutathione remains in the body longer than regular glutathione, enhancing its antioxidant effects.

Reference: Averill-Bates DA. The antioxidant glutathione. Vitam Horm. 2023;121:109-141. DOI: 10.1016/bs.vh.2022.09.002. Epub 2023 Jan 13. PMID: 36707132.

② Skin Health Improvement: S-Acetyl Glutathione inhibits melanin production, brightens skin tone, and reduces oxidative stress, helping to prevent skin aging. Its antioxidant properties also contribute to maintaining skin elasticity and hydration. Studies show that oral supplementation of 250 mg/day of glutathione (both reduced and oxidized forms) has various beneficial effects on skin properties and may serve as an anti-aging agent, particularly in middle-aged women.

Reference: Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017 Apr 27;10:147-153. DOI: 10.2147/CCID.S128339. PMID: 28490897; PMCID: PMC5413479.

③ Immune System Boost: S-Acetyl Glutathione activates immune cells, enhancing defense against infections and inflammation. It is particularly effective in combating viral infections and is beneficial for individuals with weakened immune systems.

Reference: Morris D, Khurasany M, Nguyen T, Kim J, Guilford F, Mehta R, Gray D, Saviola B, Venketaraman V. Glutathione and infection. Biochim Biophys Acta. 2013 May;1830(5):3329-49. DOI:: 10.1016/j.bbagen.2012.10.012. Epub 2012 Oct 23. PMID: 23089304.

Why is S-Acetyl Glutathione Special?

Unlike regular glutathione, S-Acetyl Glutathione is not broken down during digestion, offering superior absorption and effective supplementation. This makes it an ideal choice for consumers seeking to maximize detoxification, antioxidant benefits, and immune support.