WOMEN PLUS 60 capsules

ROKIT America’s WOMEN PLUS combines three scientifically formulated key ingredients—Trans-Resveratrol, Quercetin Dihydrate, and Active Folate—to provide various health benefits such as enhanced immunity, antioxidant support, and improved brain health.

(1) Trans-Resveratrol

Resveratrol is a polyphenolic antioxidant compound found in grape skins, blueberries, and peanuts, known for its antioxidant, anti-inflammatory, and anti-aging effects.

WOMEN PLUS utilizes Trans-Resveratrol, a more stable and bioavailable form of resveratrol, instead of the commonly used cis-resveratrol.

[Structural Differences]

The main structural difference between trans-resveratrol and cis-resveratrol lies in the position of hydroxyl groups:

- Trans-Resveratrol: Hydroxyl groups are positioned on opposite sides of the molecule.
- Cis-Resveratrol: Hydroxyl groups are positioned on the same side of the molecule.

(Images of molecular structures can be included here for clarity.)

This structural difference gives trans-resveratrol a more stable molecular configuration, resulting in the following advantages:

① Higher Bioavailability: Due to its structural stability, trans-resveratrol remains active in the body for a longer duration and is more effectively utilized.
② Enhanced Antioxidant Effect: The structural stability of trans-resveratrol enables it to combat oxidative stress more effectively than cis-resveratrol.
③ Increased Efficacy: Improved bioavailability allows for similar benefits at lower doses compared to higher doses of standard resveratrol.

(2) Quercetin Dihydrate

Quercetin is a flavonoid antioxidant compound commonly found in various fruits and vegetables, such as onions, apples, berries, green tea, and red wine. Its key benefits include antioxidant activity, anti-inflammatory effects, immune support, cardiovascular health improvement, and allergy suppression.

In ROKIT America’s WOMEN PLUS, quercetin is formulated as dihydrate quercetin, a superior form that enhances solubility and bioavailability, making it more effective than standard quercetin.

① Enhanced Solubility: Quercetin dihydrate has two water molecules attached to each quercetin molecule, allowing it to dissolve more easily in water-based solutions.
② Increased Bioavailability: Improved solubility enables the body to absorb and utilize quercetin more efficiently, meaning a greater proportion of the ingested quercetin is actively used by the body.
③ Improved Stability: The bonded water molecules help protect quercetin from damage and oxidation, ensuring its effectiveness over time.

(3) 5-Methyltetrahydrofolate

Folate, abundant in leafy green vegetables like broccoli, spinach, and avocados, is a water-soluble vitamin essential for cell growth and DNA synthesis, particularly crucial for fetal development during pregnancy.

While regular folate needs to be converted into its active form, 5-Methyltetrahydrofolate (5-MTHF), to be utilized by the body, this conversion may not function efficiently in individuals with issues in folate metabolism. Active folate eliminates this challenge by being directly available for use.

① Immediate Usability: Active folate is in a ready-to-use form, bypassing the conversion process required by regular folate, allowing for quicker absorption and utilization.
② Resolves Folate Metabolism Issues: For individuals with genetic variations in the MTHFR enzyme, which hinders the efficient utilization of regular folate, active folate provides a direct solution.
③ Cardiovascular Health Support: Active folate effectively reduces homocysteine levels, a risk factor for cardiovascular diseases, providing better health benefits with lower doses.
④ Prevents Vitamin B12 Deficiency Masking: Unlike regular folate, active folate does not mask symptoms of vitamin B12 deficiency, ensuring safer supplementation.

By being directly absorbable and functional, active folate works synergistically with Trans-Resveratrol and Quercetin Dihydrate, enhancing overall health benefits such as improved cardiovascular health, antioxidant effects, and cellular protection.

(1) Benefits of Trans-Resveratrol

• Antioxidant Effect

Mechanism: Reactive oxygen species (ROS) are naturally produced in the body but can accumulate excessively, causing cellular damage and accelerating aging. Trans-resveratrol effectively removes these ROS, reducing oxidative stress.

Research Evidence: Studies show that resveratrol increases the activity of antioxidant enzymes such as SOD (superoxide dismutase) and CAT (catalase), contributing to anti-aging, preventing cellular damage, and reducing skin aging.

Reference: 헬스미디어, Resveratrol의 항산화 효과https://www.healthmedia.co.kr/news/articleView.html?idxno=50857

• Anti-Inflammatory Effect

Mechanism: Chronic inflammation is a major contributor to diseases like cardiovascular conditions, diabetes, and obesity. Trans-resveratrol inhibits inflammatory pathways such as the NF-κB pathway, reducing the production of inflammatory mediators like TNF-α and IL-6. Benefits: This action supports the management of arthritis, chronic inflammation, and metabolic syndrome.

Dotted arrows indicate mechanisms not fully understood, while solid arrows indicate activation or inhibition pathways. Resveratrol regulates critical signaling pathways, directly and indirectly protecting cells from inflammation.

Reference: de Sá Coutinho D, Pacheco MT, Frozza RL, Bernardi A. Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights. Int J Mol Sci. 2018 Jun 20;19(6):1812. doi: 10.3390/ijms19061812. PMID: 29925765; PMCID: PMC6032205.

• Cardiovascular Health

Mechanism: Trans-resveratrol plays a crucial role in preventing cardiovascular diseases by promoting blood vessel dilation, improving blood flow, regulating blood pressure, and reducing LDL cholesterol levels. Research Evidence: Studies indicate that trans-resveratrol reduces oxidative stress in vascular endothelial cells, promoting blood vessel dilation and enhancing circulation.

Bonnefont-Rousselot D. Resveratrol and Cardiovascular Diseases. Nutrients. 2016 May 2;8(5):250. doi: 10.3390/nu8050250. PMID: 27144581; PMCID: PMC4882663.

• Neuroprotection

Benefits: Trans-resveratrol protects brain cells and supports neurological health, helping to prevent neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Mechanism: Resveratrol increases levels of BDNF (Brain-Derived Neurotrophic Factor), improving memory and learning ability.

• Anti-Cancer Effect

Mechanism: Trans-resveratrol induces apoptosis (programmed cell death) and inhibits the proliferation of cancer cells. Research Focus: It has shown inhibitory effects on breast cancer, prostate cancer, and colon cancer by suppressing cancer cell growth and regulating the cell cycle to trigger apoptosis.

(2) Benefits of Quercetin Dihydrate

• Antioxidant Effect

Mechanism: Quercetin has strong antioxidant properties that eliminate reactive oxygen species (ROS) and reduce oxidative stress. By increasing the activity of antioxidant enzymes like SOD (superoxide dismutase), quercetin helps delay cellular aging.

Reference: Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008 May 13;585(2-3):325-37. doi: 10.1016/j.ejphar.2008.03.008. Epub 2008 Mar 18. PMID: 18417116.

• Anti-Inflammatory Effect

Mechanism: Quercetin regulates the immune system, enhancing the response against viral infections. It inhibits inflammatory pathways, including the NF-κB pathway, blocking the production of inflammatory mediators like TNF-α and IL-6, thereby alleviating symptoms of chronic inflammation-related diseases such as arthritis, obesity, and cardiovascular conditions.

Model Explanation: Quercetin prevents TNF-α-induced activation of inflammatory genes and proteins, indirectly countering inflammation by antagonizing transcription factors like NF-κB and AP-1.

Reference: Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y. Quercetin, Inflammation and Immunity. Nutrients. 2016 Mar 15;8(3):167. doi: 10.3390/nu8030167. PMID: 26999194; PMCID: PMC4808895.

• Immune Support

Mechanism: Quercetin enhances the activity of immune cells like T cells and B cells, boosting the body’s defense against viruses and bacteria. Research Evidence: Quercetin has been shown to inhibit the replication of cold and flu viruses, reducing the spread of infections and mitigating resistance to antiviral treatments.

Reference: 퀘르세틴과 비타민 D는 코로나바이러스에 대항하는 아군일까요? https://korean.mercola.com/sites/articles/archive/2020/03/27/%ED%80%98%EB%A5%B4%EC%84%B8%ED%8B%B4-%EB%B9%84%ED%83%80%EB%AF%BC-d-%EC%BD%94%EB%A1%9C%EB%82%98%EB%B0%94%EC%9D%B4%EB%9F%AC%EC%8A%A4-%EC%98%88%EB%B0%A9.aspx

• Cardiovascular Health

Mechanism: Quercetin reduces LDL cholesterol (bad cholesterol) and promotes vasodilation. It stimulates the production of nitric oxide (NO), improving blood flow and preventing the oxidation of LDL cholesterol. These effects help reduce the risk of hypertension and atherosclerosis.

• Anti-Allergic Effect

Mechanism: Quercetin inhibits the release of histamines, alleviating allergy symptoms. It helps prevent and manage conditions like allergic rhinitis, asthma, and atopic dermatitis.

(3) Benefits of Active Folate

• Prevention of Neural Tube Defects

Active folate plays a crucial role during early pregnancy, particularly in weeks 3 to 4, when the fetal brain and spinal cord are forming. A lack of folate during this critical period can lead to congenital abnormalities such as neural tube defects (NTDs). Unlike regular folate, active folate can be immediately utilized by the body without requiring conversion, making it more effective in supporting the health of both the mother and fetus.

Research indicates that sufficient intake of active folate prior to pregnancy can reduce the risk of NTDs by more than 50%..

Reference: Folic acid for the prevention of neural tube defects. American Academy of Pediatrics. Committee on Genetics. Pediatrics. 1999 Aug;104(2 Pt 1):325-7. doi: 10.1542/peds.104.2.325. PMID: 10429019.a

• Cardiovascular Health

Active folate contributes to lowering blood homocysteine levels, which is crucial for cardiovascular health. Elevated homocysteine concentrations can damage arteries and lead to blood clots, significantly increasing the risk of cardiovascular diseases. Active folate aids in the methylation of homocysteine, converting it into methionine, which also supports red blood cell production and overall vascular health.

Reference: 바이오타임즈, 혈관 질환을 유발하는 호모시스테인, 엽산과 비타민B12 함께 섭취하면 도움 https://www.biotimes.co.kr/news/articleView.html?idxno=11311

• Mental Health and Mood Support

Folate is essential for the synthesis of neurotransmitters, particularly in regulating serotonin, known as the "happiness hormone," and dopamine, a key component of the brain's reward system. By supporting the production and balance of these neurotransmitters, folate can help alleviate depression and anxiety.

ROKIT WOMENPLUS combines three key ingredients, creating synergistic effects that enhance their individual benefits.

• Synergy in Antioxidant and Anti-Inflammatory Action

Trans-Resveratrol and Quercetin both possess antioxidant and anti-inflammatory properties. Together, they effectively eliminate reactive oxygen species (ROS) and suppress inflammatory pathways (e.g., NF-κB), preventing cellular aging and neurodegeneration.

• Enhanced Brain Health

Both Trans-Resveratrol and Quercetin improve neuroprotection, promoting in memory and learning capacity enhancement.

• Improved Cardiovascular Health

Folate reduces homocysteine levels, promoting cardiovascular health. When combined with the antioxidant effects of Trans-Resveratrol and Quercetin, it provides a powerful synergy for preventing cardiovascular diseases.

Why Choose ROKIT America’s WOMENPLUS?

1. High-Quality Ingredients with Optimal Ratios

WOMENPLUS is formulated with Trans-Resveratrol, Quercetin Dihydrate, Active Folate, and other nutrients tailored to women’s health, ensuring the optimal balance for maximizing individual benefits and synergistic effects.

2. Enhanced Absorption and Bioavailability

The product uses advanced ingredients with improved absorption, ensuring effective action within the body.

3. Safety and Research-Based Manufacturing

Crafted with carefully verified ingredients, WOMENPLUS undergoes meticulous quality control at every stage of production. It is manufactured in NSF GMP-certified facilities in the United States, ensuring dependable and consistent quality.

4. A Formula Designed for Women’s Health

WOMENPLUS addresses key health concerns for women, such as stress relief, memory enhancement, and homocysteine level reduction, providing comprehensive support for overall well-being.