NMN Pterosteelben 60 Capsules

NMN (Nicotinamide Mononucleotide) is a precursor to NAD+, a vital coenzyme found in all cells of the body. NAD+ plays an essential role in various biological processes, including energy metabolism, DNA repair, and the regulation of cellular aging.

NAD+ levels naturally decline with age, but this can be supplemented through NMN intake. Since NAD+ itself cannot be absorbed directly into the body, consuming NMN, which converts to NAD+ within the body, is the most effective method. Harvard University’s pioneering aging researcher, David A. Sinclair, highlighted NMN supplementation as a key to managing aging in his book Lifespan: Why We Age – and Why We Don’t Have To bringing global attention to its potential benefits.

ROKIT America, in collaboration with ROKIT Healthcare, is spearheading the global anti-aging market by utilizing rigorously verified "ROKIT NMN" ingredients. The exceptional qualities of ROKIT NMN products are as follows:

Science-Based Research:

ROKIT America develops its products based on the safety testing results of ROKIT NMN conducted jointly with ROKIT Healthcare. To validate the safety of NMN, it is essential to confirm the absence of toxicity in the raw materials through comprehensive toxicity testing. This is a critical factor in building trust in the product. ROKIT Healthcare has conducted the following tests to demonstrate the safety of ROKIT NMN:

High Purity and Superior Absorption:

ROKIT America’s NMN products are manufactured with 99.9% purity, ensuring exceptional absorption within the body. The product is formulated with precise amounts of high-quality raw materials to maximize its effectiveness at the cellular level.

Safety and Verified Quality:

Each ROKIT NMN product undergoes stringent quality control measures and is manufactured in compliance with international standards. This ensures the delivery of safe and reliable products that users can trust.

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a natural polyphenol compound primarily found in blueberries. Known for its higher bioavailability compared to other stilbene compounds, pterostilbene can significantly enhance the absorption efficiency of NMN. Studies have shown that pterostilbene’s bioavailability is approximately 80%, compared to only 20% for resveratrol, while offering many of the same beneficial biological regulatory effects as resveratrol.

Key Benefits and Functions of Pterostilbene:

• Powerful Antioxidant Activity: Pterostilbene effectively eliminates reactive oxygen species (ROS) and reduces oxidative stress (OS), playing a crucial role in antioxidant defense. Its antioxidant properties are linked to benefits such as anti-cancer effects, neurological disease management, anti-inflammatory effects, vascular health improvement, and diabetes alleviation.
• AMPK Activation: Pterostilbene activates AMPK, improving insulin resistance and promoting autophagy in the body. Enhanced autophagy activates SIRT2 proteins, which are essential for cell survival, DNA repair, antioxidant activity, and metabolic regulation.
• Inflammation Mitigation in Osteoarthritis: Studies have shown that administering pterostilbene to mice with osteoarthritis reduced inflammatory mediators like COX-2, iNOS, and PGE2 induced by IL-1β. Additionally, mitochondrial and intracellular ROS production was significantly suppressed. Since COX-2 and PGE2 are key mediators of inflammation-induced osteoarthritis pain, these findings suggest that pterostilbene can effectively reduce low-level inflammation in cartilage cells.

Xue EX, Lin JP, Zhang Y, Sheng SR, Liu HX, Zhou YL, Xu H. Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway. Oncotarget. 2017 Jun 27;8(26):41988-42000. doi: 10.18632/oncotarget.16716. PMID: 28410217; PMCID: PMC5522043.

Neuroprotective Effects:

• Effective Blood-Brain Barrier Penetration: Pterostilbene effectively crosses the blood-brain barrier, helping to prevent neurodegenerative diseases.
• Reduction of Oxidative Stress and Inflammation in Neural Tissue: It reduces oxidative stress and inflammation in neural tissue, enhancing cognitive function and memory. Studies have demonstrated that aged mice supplemented with pterostilbene showed improvements across various indicators, including cognitive abilities, behavior, memory tests, and mitochondrial function, which is the primary energy source for cells.
• Enhancement of Learning and Memory Proteins: Pterostilbene supplementation increased the expression of PSD-95, a protein involved in learning and memory formation. This suggests its potential to alleviate functional impairments associated with Alzheimer’s disease.

▲ Behavioral Assessment of Pterostilbene's Effects on Cognitive Function.

In (A), there was no difference between the two groups before treatment (p = 0.619), but after pterostilbene administration, the pterostilbene-treated group showed better performance compared to the control group (p = 0.013). In (B), the pterostilbene-treated group demonstrated a superior ability to distinguish objects compared to the control group (p = 0.003). In both (C) and (D), the pterostilbene-treated group outperformed the control group, successfully distinguishing between the two objects at both 1-hour and 24-hour intervals (p < 0.001 and p = 0.002, respectively).

La Spina M, Sansevero G, Biasutto L, Zoratti M, Peruzzo R, Berardi N, Sale A, Azzolini M. Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. Cell Physiol Biochem. 2019;52(2):232-239. doi: 10.33594/000000017. Epub 2019 Feb 28. PMID: 30816671.

Cardiovascular Health:

• Helps lower LDL cholesterol and triglyceride levels while increasing HDL cholesterol.
• Prevents lipid oxidation, reducing the risk of atherosclerosis and cardiovascular diseases.

Metabolic Health and Diabetes Management:

• Improves insulin sensitivity and regulates blood sugar levels.
• Enhances lipid metabolism, supporting weight management.

Anticancer Potential:

• Induces apoptosis (programmed cell death) in cancer cells and inhibits their proliferation.
• Demonstrates efficacy against various cancer cell lines, including breast, colon, and lung cancers.

Synergy Between NMN and Stilbene Compounds: Cellular Protection and Anti-Aging Effects

Research indicates that combining NAD+ boosters like NMN with stilbene compounds amplifies their antioxidant and anti-aging effects.

Co-administration of NMN and Resveratrol: This combination resulted in higher NAD+ levels in the heart and skeletal muscles compared to NMN alone.
• Co-administration of NMN and Ginsenosides: This pairing maximized NAD+ levels in brain, heart, kidney, and lung tissues, significantly surpassing the effects of NMN alone.
• Co-administration of NR and Pterostilbene: In patients with acute kidney injury, this combination increased NAD+ levels by 40% and 90% after two doses, with consistent improvements observed throughout an 8-week trial period.

Thus, the combination of NMN with stilbene compounds represents an optimal approach for maximizing NAD+ levels and supporting longevity.

Sharma A, Chabloz S, Lapides RA, Roider E, Ewald CY. Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients. 2023 Jan 14;15(2):445. DOI: 10.3390/nu15020445. PMID: 36678315; PMCID: PMC9861325.

Synergy Between NMN and Pterostilbene: Cellular Protection and Anti-Aging Effects

The synergy observed when NMN and Pterostilbene are taken together stems from their complementary mechanisms of cellular protection.

• Increased Cellular Energy Through NAD+ Supplementation: NMN boosts NAD+ levels, enhancing cellular energy, aiding cell regeneration, and promoting lifespan extension.
• Antioxidant and Anti-inflammatory Effects: Pterostilbene reduces oxidative stress and suppresses inflammatory responses, preventing cellular damage and maintaining a healthy cellular environment.

When combined, these mechanisms reinforce cellular resilience, protect against oxidative and inflammatory damage, and ensure sufficient cellular energy. This synergy results in enhanced fatigue recovery, chronic disease prevention, and amplified anti-aging effects.

Stilbene Compounds: Pterostilbene vs. Resveratrol

When NMN is paired with Pterostilbene, the combined effects include NAD+ elevation for energy production and Pterostilbene's antioxidant properties, offering multifaceted cellular protection. This is because NMN converts into NAD+ within cells, serving as fuel for the longevity gene Sirtuin, while Pterostilbene acts as a Sirtuin activator. Research highlights that compared to Resveratrol, Pterostilbene is a safer and longer-lasting compound for delaying aging through sustained NAD+ presence in the body. Additionally: Conversion of Resveratrol to Pterostilbene: Resveratrol undergoes O-Methyltransferase action, replacing two hydroxyl hydrogen atoms with methyl groups to form Pterostilbene. Enhanced Retention and Absorption: Pterostilbene, being lipophilic, delays the excretion of NMN, allowing it to remain in the body longer. Furthermore, while Resveratrol has low oral bioavailability, Pterostilbene is absorbed over four times more efficiently. In conclusion, the combination of NMN and Pterostilbene not only boosts NAD+ levels but also amplifies the individual benefits of both compounds, making it the "optimal anti-aging formula."