NMN Latest Paper (3) Kidney Function

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This time, we will introduce the latest paper on NMN and kidney function .

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• NMN

NMN (Nicotinamide mononucleotide) began to receive attention as a representative anti-aging substance in Korea after being mentioned by David A. Sinclair , a pioneer in aging research at Harvard University .

When NMN is consumed , it is converted into NAD+ , an essential coenzyme in the body, which effectively improves symptoms that may occur as we age .

For example, at the ages of 34 , 60 , and 78 , there comes a time when the level of aging proteins increases rapidly , and NAD+ helps maintain healthy youth by lowering this level .

As papers on the efficacy of NMN, which is converted into NAD+ in the body, continue to be published, I would like to introduce papers related to kidney function among them .

• NMN and kidney function

Before we go on, let’s briefly explain about our body’s organ, the “ kidney . ”

The kidneys are located in pairs on the back of the lower abdomen and are one of the important organs that excrete waste products and maintain homeostasis in the body, such as acid-base and electrolyte metabolism .

In particular, they perform the function of filtering unnecessary substances from the bloodstream, which is very important for maintaining life . As we age, kidney scarring and tissue hardening can impair the kidneys' ability to filter blood, which can lead to glomerulosclerosis, which causes proteins to leak into the urine .

As glomerulosclerosis becomes severe, dialysis or kidney transplantation may be required , and various studies are being conducted to find ways to slow the progression of kidney damage .

Wakino and colleagues at the University of Tokushima, Japan, administered 500 mg/kg/day of NMN for two weeks to investigate the effects of NMN on kidney function and reported the results in Scientific Reports .

Here are a few things to keep in mind to help you understand the graph below :
Cont is a mouse model administered saline .

ADR is a mouse model of focal glomerulosclerosis (FSGS) .

NMN500 is a mouse model administered with NMN .

(Hasegawa et al., 2022 | Scientific Reports )

The researchers demonstrated that NMN improved kidney function in three mouse models, based on the results of the ACR (to-creatinine ratio) , a measure of urine protein levels, which indicates that high urine protein levels are linked to kidney damage and filtration disorders .

According to the graph on the right , you can see that the cells essential for kidney waste filtration, called podocytes, were significantly higher in those administered NMN compared to ADR .

These results provide the first evidence that NMN restores waste-filtering cells in kidney disease .

(Hasegawa et al., 2022 | Scientific Reports )

Additionally, NMN increases the activation of the longevity-promoting enzyme Sirtuin-1 by enhancing nicotinamide adenine dinucleotide (NAD+) , a molecule essential for cellular health, thereby reducing enzymes associated with kidney tissue damage .

According to the picture above , the pink part represents kidney tissue and fat tissue , and the white part represents lesions, and more lesions appear in the ADR mouse model compared to NMN500 .

These results provide a second line of evidence that NMN prevents lesions in renal disease and restores renal function .

As such, NMN has shown various positive effects throughout the body in preclinical areas.

We will continue to introduce the latest papers on the efficacy of NMN .

thank you !

ROKIT America NMN is a blend of high-purity NMN and pterostilbene, which enhances the absorption of NAD+ .

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Additional information can be found by clicking on the photos below .

We will come back with more useful health information next time .

thank you !

[References ]

[1] Naver Encyclopedia , “ Kidney ”

[2] NMN.com, “NMN Prevents Kidney Damage and Restores Kidney Function, Japanese Study Indicates”

[3] Hasegawa K, Sakamaki Y, Tamaki M, Wakino S. Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD consumers mediated by Twist2. Sci Rep. 2022 Aug 12;12(1):13712. doi: 10.1038/s41598-022-18147-2. PMID: 35962139; PMCID: PMC9374671.