NMN for Cancer? NMN Reduces Cancer Treatment Side Effects
This time, we will introduce the latest paper regarding the reduction of side effects of NMN cancer treatment .
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NMN
Nowadays, people pursue maintaining a healthy life rather than simply living a long life . However, people generally reach a point where their aging protein levels rapidly increase around the ages of 34 , 60 , and 78 , so they want to effectively improve the symptoms of aging that can occur as they age through intermittent fasting , regular exercise , and NMN intake .
Since papers on the efficacy and effectiveness of NMN , which is converted into NAD+ in the body, are continuously being published, I would like to introduce papers related to reducing side effects of cancer treatment .
To make the paper easier to understand, I will explain two words and move on .
- Cisplatin: A chemotherapy drug used to treat cancers such as lung cancer , testicular cancer , ovarian cancer, and breast cancer , and a representative side effect caused by this drug is chemobrain .
- Chemobrain: Refers to cognitive impairment caused by chemotherapy, including impairments in memory , attention, and information processing .
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NMN and cancer
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NMN and Reducing Cancer Treatment Side Effects (1)
Our bodies are made up of various cells . Among them, mitochondria, which play a crucial role in cellular function, cause DNA damage and increase the production of mitochondrial reactive oxygen species (mROS) when combined with cisplatin . In particular, mitochondrial reactive oxygen species cause cell damage ( oxidative stress ) , so the higher the level, the more negative the effects on the body .
To prove this, Rashid and his colleagues took stem cells from a 16 -year-old male, chemically modified them into cortical neurons, and compared them . In the graph below, Saline was treated with saline , then exposed to cisplatin for 24 hours , while NMN was pretreated for 30 minutes and then exposed to cisplatin for 24 hours . After NMN pretreatment , the reduction in side effects due to cisplatin can be confirmed by comparing the levels of cisplatin (CIS) in the 𝛾-H2AX index, which indicates DNA damage, and ( cisplatin )CIS in the reactive oxygen species (mROS) index .
( Rashid et al., 2023 | Brain Plasticity )
When pretreated with NMN for 30 minutes , cisplatin (CIS) levels were significantly lower in the 𝛾-H2AX index on the left and the reactive oxygen species (mROS) index on the right .-
NMN and Reducing Cancer Treatment Side Effects (2)
( Rashid et al., 2023 | Brain Plasticity )
Rashid and his colleagues measured mitochondrial swelling by assessing the size of mitochondria using a powerful ( transmission electron ) microscope . The larger the area of cisplatons , the greater the mitochondrial neuronal damage .Analyzing the graph above , we can see that neurons treated with cisplatin (CIS) and saline ( orange ) have larger mitochondrial areas . However, neurons treated with NMN ( blue ) have smaller mitochondrial areas . Based on the findings in these papers, our results suggest that NMN may potentially help prevent brain aging and neurodegeneration, particularly in response to chemotherapy such as cisplatin . Additionally, NMN has been shown to prevent heart damage in response to doxorubicin, a chemotherapy for cancers such as leukemia , and to prevent intestinal wall damage in response to radiation therapy, which is commonly used to treat abdominal and pelvic tumors in older adults . Therefore, with further research, we may see more evidence showing that NMN may help prevent side effects of various cancer treatments .
As NMN has shown various positive effects throughout the body in preclinical studies, we will continue to introduce the latest papers on the efficacy of NMN .
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