NMN whitening effect
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"NMN prevents excessive production of melanin pigment in aging melanocytes."
Melanin production mechanism
You've probably noticed blemishes dotting your face when you look in the mirror. This is due to melanin, which not only causes blemishes but also pigmentation such as freckles and dark spots. Melanin naturally acts as a defense mechanism, protecting the skin from external irritants. Specifically, it absorbs UV rays, preventing them from penetrating deep into the skin and damaging cellular DNA. Therefore, prolonged exposure to UV rays can accelerate melanin production, inevitably leading to an increase in blemishes. Furthermore, melanin can be overproduced during rapid hormonal changes, such as pregnancy , or it can abnormally increase in scar tissue after inflammation , leaving behind pigmentation. Furthermore , as we age, the number of melanocytes in the body increases, which can lead to an increase in melanin pigmentation.
When melanocytes are stimulated by reactive oxygen species for various reasons, the enzyme tyrosinase, which drives melanin biosynthesis, is activated. Tyrosinase acts as a catalyst to oxidize tyrosine, which is then converted into dopaquinone, producing dark brown or red melanin pigment. This melanin pigment accumulates in melanosomes within melanocytes and later moves to keratinocytes, where it forms visible pigmentation in the form of freckles and blemishes.
Once established, pigmentation is difficult to recover naturally and tends to darken over time. The most important way to combat pigmentation is to prevent it in the first place through UV protection. But what should you do if pigmentation has already developed?
Comparison of 'young melanocytes' and 'aged melanocytes'
Senescent melanocytes synthesize more melanin pigment than young melanocytes. Comparing young and aged melanocytes, we found that NAD+ levels were significantly lower in these cells. So, wouldn't administering NMN to aged melanocytes prevent excessive melanin production?
clinical trials
To confirm this, we administered NMN to aged melanocytes . As a result, we observed a significant decrease in melanin production in NMN-treated cells compared to untreated cells. This confirmed NMN's inhibitory effect on melanin production.
1. Aged melanocytes
▶ Results of NMN treatment on aged melanocytes
This time, to find out the in vivo effects of NMN, we applied it to the skin of 10 elderly people. µM and 20 We treated the skin with µM of NMN. As a result, we observed a decrease in melanin levels in aged human skin, similar to that observed in aged cells. This suggests that NMN has potential therapeutic potential.
2. Older people's skin
▶ Results of NMN treatment on the skin of older people
NMN can prevent pigmentation by inhibiting melanin formation. This effect suggests its potential as a treatment for pigmentation or as a whitening agent.
[References and Figure Source]
[1] https://signaturemg.co.kr/news_view.php?idx=2329&cate=&cate_sub=
