NMN Long-Lasting 30 capsules

NMN (Nicotinamide Mononucleotide) is a precursor to NAD+, a vital coenzyme found in all cells of the body. NAD+ plays an essential role in various biological processes, including energy metabolism, DNA repair, and the regulation of cellular aging.

NAD+ levels naturally decline with age. However, this can be supplemented through NMN intake. Since NAD+ itself cannot be absorbed directly into the body, consuming NMN, which converts to NAD+ within the body, is the most effective method. Harvard University’s pioneering aging researcher, David A. Sinclair, highlighted NMN supplementation as a key to managing aging in his book Lifespan: Why We Age – and Why We Don’t Have To bringing global attention to its potential benefits.

ROKIT America, in collaboration with ROKIT Healthcare, is spearheading the global anti-aging market by utilizing rigorously verified "ROKIT NMN" ingredients. The exceptional qualities of ROKIT NMN products are as follows:

Science-Based Research:

ROKIT America develops its products based on the safety testing results of ROKIT NMN conducted jointly with ROKIT Healthcare. To validate the safety of NMN, it is essential to confirm the absence of toxicity in the raw materials through comprehensive toxicity testing. This is a critical factor in building trust in the product. ROKIT Healthcare has conducted the following tests to demonstrate the safety of ROKIT NMN:

High Purity and Superior Absorption:

ROKIT America’s NMN products are manufactured with 99.9% purity, ensuring exceptional absorption within the body. The product is formulated with precise amounts of high-quality raw materials to maximize its effectiveness at the cellular level.

Safety and Verified Quality:

Each ROKIT NMN product undergoes stringent quality control measures and is manufactured in compliance with international standards. This ensures the delivery of safe and reliable products that users can trust.

NMN (Nicotinamide Mononucleotide) is converted into NAD+ upon ingestion, supporting energy metabolism in the body and playing a critical role in cellular antioxidant and anti-aging effects. However, when NMN supplements are taken orally, they are prone to rapid degradation within the body, particularly when exposed to stomach acid, which significantly reduces their absorption efficiency. This presents a limitation in achieving optimal NMN bioavailability in the body.

ROKIT America’s NMN Long-Lasting utilizes NutraJIT® technology to enhance NMN absorption. This technology prevents rapid release in the stomach, allowing sufficient time for NMN to be absorbed in the small intestine. As a result, the absorption efficiency of NMN can be increased by up to 7 times, ensuring optimal effectiveness.

Over a 7-hour sustained absorption, NMN remains in prolonged contact with the NMN transporter Slc12a8 in the small intestine. This extended interaction allows NMN to be effectively transported to various organs throughout the body, where it is converted into NAD+. The Slc12a8 transporter, abundantly present in the small intestine, is a primary pathway for direct NMN uptake into cells and plays a crucial role in maintaining NAD+ levels, especially as they decline with age.

The NAD+ distributed throughout the body acts as a vital substance for cellular energy production, contributing to enhanced physical performance, fatigue recovery, and improved skin health. Additionally, its anti-aging effects extend to DNA damage repair, inflammation suppression, and cognitive function enhancement, ultimately improving users' overall quality of life.

One of the experimental foundations supporting the enteric-coated effect of ROKIT America's NMN Long-Lasting product is based on animal study results. Research has demonstrated that when NMN is administered to mice with active NMN transporters, the absorption and conversion of NMN into NAD+ occurred efficiently, leading to various health benefits. To understand the necessity of specific functions, such as respiration or gene activity, researchers often observe changes when these functions are intentionally inhibited. This approach helps infer their roles.

• Slc12a8 Transporter in Mice: Slc12a8 is a specialized transport protein predominantly present in the small intestine, playing a crucial role in NMN (Nicotinamide Mononucleotide) absorption.
• Function Evaluation in Slc12a8 -Rich Small Intestines: The study reduced the functionality of the Slc12a8 gene in the small intestines where it is most abundantly expressed, to assess the NMN transport capability of Slc12a8.
• Impact of Slc12a8 Deficiency: Using a mouse model with artificially reduced expression of the Slc12a8 gene, researchers evaluated the effects of Slc12a8 protein deficiency on NMN absorption.

The graph illustrates that the Slc12a8 protein directly facilitates NMN absorption. When Slc12a8 is inhibited, a reduction in NAD+ levels and a subsequent decline in cellular energy metabolism were observed. These findings highlight the critical role of Slc12a8 in anti-aging processes and maintaining energy metabolism, underscoring its significance in promoting cellular health and longevity.

Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab. 2019 Jan;1(1):47-57. DOI: 10.1038/s42255-018-0009-4. Epub 2019 Jan 7. Erratum in: Nat Metab. 2019 Jul;1(7):743. DOI: 10.1038/s42255-019-0088-x. PMID: 31131364; PMCID: PMC6530925.