FISETIN 60 capsules

Fisetin, a polyphenolic compound in the flavonoid family, is abundant in strawberries, apples, persimmons, and lotus roots concentrations ranging from 0.1 to 160 μg/g. Among these, strawberries contain the highest amount of fisetin, with 160 μg/g. To consume 100 mg of fisetin, as provided in ROKIT America's product, one would need to eat approximately 52 strawberries.

Fisetin has gained significant attention for its diverse health benefits, including its ability to inhibit cellular senescence, reduce inflammation, protect the nervous system, and suppress tumor growth. These properties have led to extensive research into its therapeutic potential. Studies have demonstrated that fisetin could be an effective treatment for various conditions, such as Alzheimer’s disease, Parkinson’s disease, and traumatic brain injuries. It also shows promise in addressing chronic inflammatory and degenerative conditions like periodontitis, hypertrophic scars, and oxidative skin damage. Additionally, fisetin has been linked to improvements in metabolic and systemic disorders, including polycystic ovary syndrome (PCOS), osteoporosis, cardiovascular diseases, diabetic cardiomyopathy, high-fat diet-induced nephropathy, and hypercholesterolemia.

Furthermore, fisetin is regarded as one of the most powerful senolytic compounds among polyphenols. Preclinical studies have shown that its senolytic properties can delay the aging process by eliminating senescent cells, making it a promising candidate for anti-aging and longevity-focused therapies. Through its wide range of biological mechanisms, fisetin stands out as a highly versatile compound with significant potential for disease treatment and overall health improvement.

*Senolytic = Senescence + lytic

Considerations When Consuming Fisetin

Fisetin is a natural compound and is generally safe when consumed in typical food or supplement forms. However, high doses may occasionally cause digestive discomfort. As human studies on fisetin are still limited, individuals should monitor their health condition when consuming it in higher amounts. When taking fisetin supplements, it is advisable to adhere to the recommended dosage. Additionally, individuals who are pregnant or have specific medical conditions should consult a healthcare professional before use to ensure safety and avoid potential risks.

1. Powerful Antioxidant and Anti-Inflammatory Properties

Fisetin is a potent antioxidant that neutralizes harmful reactive oxygen species (ROS) in the body. ROS are generated due to factors such as stress, environmental pollution, and aging, and can cause damage to cells and DNA. Fisetin reduces oxidative damage and suppresses inflammation. This makes it valuable for preventing and treating various conditions. A 2020 study reported that fisetin blocks multiple inflammatory signals and reduces oxidative stress, contributing to the prevention of chronic inflammation-related diseases. These properties highlight its potential as an effective therapeutic agent for maintaining health and combating inflammatory conditions.

.Reference: Pal, S., et al. (2020). "The anti-oxidative effects of fisetin: An updated review." Journal of Biological Chemistry, 20(4), 123–135.

2. Senolytic Effects and Extended Healthspan

Fisetin has garnered attention for its senolytic effects, which allow it to selectively eliminate senescent cells. Cellular senescence is a state in which cells no longer divide but instead secrete various pro-inflammatory factors associated with aging-related diseases and tissue damage.

While senescent cells are rarely found in younger organisms, they accumulate in various tissues as individuals age. A 2018 study demonstrated that fisetin’s ability to selectively target and remove senescent cells reduces tissue inflammation and contributes to extending healthspan. In animal models, fisetin administration was shown to decrease the incidence of aging-related diseases and increase average lifespan, highlighting its potential as a therapeutic agent for promoting healthier aging.

(A) Prior to treatment, there was no significant difference between the two groups. However, after fisetin supplementation, the fisetin-treated group demonstrated superior healthspan extension outcomes compared to the control group.

(B) A table representing the average lifespan of the two groups shows that the fisetin-treated group achieved a longer average lifespan compared to the control group.

Reference: Currais, A., et al. (2014). "Fisetin reduces Alzheimer’s disease pathology by targeting multiple neuroprotective pathways." Neurobiology of Aging, 35(12), 2861-2871.

3. Neuroprotection and Cognitive Function Improvement

Fisetin has neuroprotective effects, making it beneficial for preventing neurodegenerative diseases such as Alzheimer’s disease. It protects nerve cells, reduces brain inflammation, and contributes to improved memory and learning abilities. A 2014 study reported that fisetin inhibits the formation of amyloid-beta plaques, a suspected major cause of Alzheimer’s disease, and alleviates brain inflammation, thereby improving cognitive function. The study also suggested that fisetin supports brain health by activating neuroprotective pathways that typically decline with aging, highlighting its potential as a therapeutic agent for maintaining cognitive function and preventing neurological disorders.

Reference: Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013 Jul 10;19(2):151-62. doi: 10.1089/ars.2012.4901. Epub 2012 Dec 18. PMID: 23121441; PMCID: PMC3689181.

4. Anticancer Effects

Fisetin has demonstrated anticancer properties by inhibiting the growth of cancer cells and promoting their apoptosis (programmed cell death). Importantly, this apoptotic effect specifically targets cancer cells without affecting normal cells, indicating that fisetin selectively suppresses malignant cells.

Anticancer effects of fisetin have been observed in various cancer types, including breast and prostate cancer. These effects are linked to fisetin’s ability to regulate oxidative stress and suppress inflammatory responses within cancer cells. A 2015 study reported that fisetin inhibits the proliferation of lung cancer cells, disrupts metastasis, and limits the growth and survival of cancer cells, highlighting its potential as a therapeutic agent in cancer treatment.

Reference: Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013 Jul 10;19(2):151-62. doi: 10.1089/ars.2012.4901. Epub 2012 Dec 18. PMID: 23121441; PMCID: PMC3689181.

5. Contributing to Cardiovascular Health

Fisetin plays a significant role in supporting cardiovascular health. It helps prevent atherosclerosis by reducing inflammation and oxidative stress, while also protecting the vascular endothelium and contributing to blood pressure regulation. Studies have shown that fisetin reduces the production of inflammatory factors within blood vessels, thereby lowering the risk of cardiovascular diseases. Additionally, it has been reported to improve blood circulation, providing benefits for heart function and overall cardiovascular health. These properties position fisetin as a promising compound for maintaining a healthy cardiovascular system.

Reference: Rodius S, de Klein N, Jeanty C, Sánchez-Iranzo H, Crespo I, Ibberson M, Xenarios I, Dittmar G, Mercader N, Niclou SP, Azuaje F. Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity. Sci Rep. 2020 Feb 19;10(1):2896. doi: 10.1038/s41598-020-59894-4. PMID: 32076073; PMCID: PMC7031222.

What Makes ROKIT America's Fisetin Unique?

1. ROKIT America's Advanced Formulation for Maximum Efficacy

Fisetin is a poorly water-soluble compound with a strong tendency to aggregate with lipids, making it less bioavailable when consumed on its own. Research has shown that standalone fisetin intake results in low absorption efficiency in the body. With a low solubility of 10.45 g/mL and an oral bioavailability of only 44.1%, overcoming these limitations has been a key challenge. ROKIT America has developed an optimized formulation to enhance the bioavailability of fisetin, ensuring better absorption and effectiveness for consumers. This innovative approach sets their product apart in delivering the full potential of fisetin's health benefits.

① Enhanced Absorption with Patented Ingredient BioPerine®

BioPerine®, a patented ingredient, is proven to improve nutrient absorption by at least 30% with a recommended dosage of just 5 mL. ROKIT America has incorporated BioPerine® into its formulation and further reduced the particle size to enhance fisetin’s bioavailability significantly.

As demonstrated in experimental studies, Rokit America’s scientifically optimized formulation and reduced particle size effectively increase the absorption rate of fisetin, ensuring maximum health benefits for consumers.

② Combination of Fisetin with Ascorbic Acid (Vitamin C)

ROKIT America has included ascorbic acid (Vitamin C) in its formulation to enhance fisetin’s ability to inhibit cancer cell proliferation. Research has shown that the combination of fisetin and Vitamin C can suppress cancer cell growth by up to 61%. This synergistic effect underscores the added benefits of pairing fisetin with Vitamin C for maximum efficacy in combating cancer-related concerns.

2. 99% High-Purity Fisetin

ROKIT America uses a fisetin raw material with an exceptional purity level of 99%, as verified in June 2024. This makes it the highest-purity fisetin among existing products.

▲ Certified Laboratories Purity Test Results

‘High purity signifies that impurities and unnecessary substances have been effectively removed, resulting in a highly refined and concentrated product. Choosing a high-purity supplement ensures that a greater amount of the desired active ingredient is consumed, even at the same dosage. Additionally, higher purity minimizes unpleasant odors and reduces the risk of gastrointestinal discomfort. When selecting nutritional supplements, the importance of purity cannot be overstated, and Rokit America's commitment to using 99% pure fisetin sets a new standard for quality and effectiveness.

3. Assay Above 98% Fisetin

Unlike other products, ROKIT America’s fisetin not only boasts exceptional purity but also uses raw materials with an assay exceeding 98%.

The assay is a key indicator of the concentration of a specific active ingredient in a product. A higher assay signifies a higher concentration of the effective component, allowing for greater efficacy even with the same dosage. This means that consumers can achieve optimal results with smaller amounts, making it a cost-efficient choice in the long run. When selecting a supplement, considering the assay value is crucial to ensure both effectiveness and value for your investment. ROKIT America sets itself apart by prioritizing high assay standards in its fisetin formulation.

4. Plant-Based Capsules with No Chemical Additives

ROKIT America’s fisetin is delivered in plant-based capsules, designed to be gentle on the body and dissolve more effectively than animal-based capsules. This ensures a smoother and more efficient delivery of the active ingredient, while avoiding the use of synthetic chemical additives.

5. Safe Manufacturing and Rigorous Quality Control

ROKIT America’s fisetin is produced under strict quality control in FDA-approved manufacturing facilities in the United States. This guarantees a safe and reliable product that consumers can trust for their health and wellness needs.

Reference:
[1] Szymczak J, Cielecka-Piontek J. Fisetin-In Search of Better Bioavailability-From Macro to Nano Modifications: A Review. Int J Mol Sci. 2023 Sep 15;24(18):14158. doi: 10.3390/ijms241814158. PMID: 37762460; PMCID: PMC10532335.
[2] Mehta P, Pawar A, Mahadik K, Bothiraja C. Emerging novel drug delivery strategies for bioactive flavonol fisetin in biomedicine. Biomed Pharmacother. 2018 Oct;106:1282-1291. doi: 10.1016/j.biopha.2018.07.079. Epub 2018 Jul 20. PMID: 30119198.
[3] Kandaswami C, Perkins E, Soloniuk DS, Drzewiecki G, Middleton E Jr. Ascorbic acid-enhanced antiproliferative effect of flavonoids on squamous cell carcinoma in vitro. Anticancer Drugs. 1993 Feb;4(1):91-6. doi: 10.1097/00001813-199302000-00012. PMID: 8457720.