David Sinclair Unleashes Longevity Genes, Says "The Age of 120 Is Coming"

'Aging is not normal, it is a disease, and this disease is treatable.'

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In 2020 , Dr. Sinclair, a professor at Harvard Medical School, garnered much attention by publishing " The End of Aging, " a compilation of 25 years of longevity research .

Most people have accepted aging and death as an inevitable fate . However , Dr. Sinclair argues that aging is not normal, but a " disease . " And by "disease," I mean , something that can be treated and overcome .

Dr. David Sinclair, who recently had a video interview with the Korea Economic Daily, expressed the same position again .

' The human belief that aging is a natural phenomenon that occurs with age is no longer valid. '

He claims that aging can be reversed, not just delayed or stopped , and that if only aging could be addressed, everyone would be able to live a long and healthy life, free from all disabilities and diseases . He presents scientific evidence that when the era of ' reverse aging ' arrives , which reverses the human body's biological clock, the human lifespan, currently around 80 years, can be extended to 120 years . Most importantly, he does not stop at extending the average lifespan, but argues for extending the ' healthy lifespan ' , a healthy lifespan without disease .

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Dr. David Sinclair likens the discovery of "reverse aging" to "human flight."

The longevity drugs that reverse aging are revealed through ' The End of Aging ' , the drugs suggested in the book include rapamycin , metformin , resveratrol , NR (Nicotinamide riboside), and NMN (Nicotinamide mononucleotide) . He likens these discoveries to the Wright brothers ' ' first flight ' .

There are events in human history that make it impossible for the world to return to its previous state. Flight is a good example. We can't go back to the time before the Wright brothers. Before then, only birds could fly, and humans couldn't fly to nearby cities. But the moment the Wright brothers appeared, everything changed. Now, hundreds of thousands of people travel by airplane every day. The same goes for aging research. However, anti-aging, or even reverse aging, has never been observed before, so we believe it's impossible.

Dr. David Sinclair says the era of 'anti-aging' will arrive 10 years or more early . When the era comes where humans can control their own biological age , they will look back and think, ' There was a time when we couldn't even control our own aging . ' Just as we look back on the history of aviation and think , ' There was a time when it took months to get to a neighboring country because there were no airplanes . '

Reverse aging is no longer a question of "if" but "when."

Dr. David Sinclair mentioned Jeanne Calment, the ' world's oldest person ' who lived to be 122 , and said , ' Currently , the average life expectancy in developed countries is about 80 years , but the gap of 40 years in the meantime can be reduced through anti-aging research , etc.' He also said that just as humans did not immediately fly across the continent after the Wright brothers succeeded in the first flight , we should focus on ' when ' rather than ' if' , even though it may not happen right away .

When drugs were administered to mice with damaged optic nerves, their vision was restored and their muscle strength was strengthened.

The cause of human aging, as he revealed in ' The End of Aging ' , is epigenetic noise . When epigenetic noise occurs due to various variables such as the environment or sirtuin (NAD+ dependent deacetylase) genes, genes are not regulated in the desired direction, causing cells to lose their identity and become dysfunctional or take on different functions . As we age, epigenetic noise accumulates , the expression of aging genes progresses , the suppression of essential genes progresses, and aging occurs .

In this interview, Dr. Sinclair mentioned the development of an anti-aging treatment based on a substance that activates the longevity gene, sirtuin . He also mentioned research cases where the symptoms of macular degeneration were improved by removing senescent cells , and research cases where glaucoma treatment was approached through cell reprogramming, revealing that research on ' reversing aging ' is continuously being conducted .

For example , regarding the study of ' old blind mice ' recently published in the scientific journal Cell , it is said that ' it goes beyond simply curing blindness and proves that safe reversal of aging is possible .' The research team intentionally damaged the optic nerves of young mice, whose optic nerves recover more easily than those of old mice , and then developed a cell reprogramming technology that targets the genetic mutations that appeared to create a drug . This was administered to old mice , and as a result, vision was restored and muscles and brain tissue became healthy . This research is currently being tested in other tissues, such as the brain, as well as the eyes .

There is clearly a drug that, when administered to old mice, makes them more energetic and stronger. Reversing aging is real. It's imminent.

Meanwhile , NMN and NR , the longevity drugs mentioned in 'The End of Aging ' , are both precursors of NAD . NAD (Nicotinamide adenine dinucleotide) , which is a coenzyme for cellular activity and contributes to bioenergy production, decreases with age . Conversely, when the level of NAD within the cell increases, sirtuin genes are activated, the functions of the brain , blood vessels , and muscles are improved, and inflammation is reduced, so aging can be prevented . However, since NAD+ is a very large molecule that cannot directly enter the cell, NMN or NR , which are converted to NAD+ in the body instead of NAD + and can pass through the cell membrane, are used as longevity drugs .

Resveratrol also has life-extending effects by activating sirtuin genes . This is known to help with various diseases, including antiviral , anti-aging , anti-inflammatory , and life-extending properties .

Aging is a treatable disease

The U.S. Food and Drug Administration (FDA) also agrees that aging is a treatable disease . However , it wants real-world evidence, and several clinical trials are being prepared around the world .

Meanwhile , the FDA has decided to ban the sale of NMN , which was mentioned in ' The End of Aging ' , as it does not consider it a dietary supplement . This is because NMN has been approved for research as a new drug and has been the subject of clinical studies . In other words , the ban on the sale of NMN was not caused by the side effects of the raw material, but rather due to the ongoing drug review . Rather, this has become an issue because it disproves the excellent efficacy and effectiveness of NMN itself in reversing aging .

What message do you want to emphasize?

Finally , Dr. David Sinclair concluded the interview by saying, ' I hope more people realize how much stopping aging can change the quality of our lives . '

Rocket America will also become a company that constantly listens to its consumers to improve their quality of life and help them change to a healthier body .

We ask for your continued interest in the ‘ anti-aging ’ brand Rocket America .

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[1] “ Aging is a treatable disease …even those in their 80s will have the ‘vitality of a 40 -year-old ’ ”: https://www.hankyung.com/article/2024031758871